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Paracoccidioidomycosis (PCM) is an endemic disease geographically restricted to Latin America, from Mexico to Argentina; Brazil is the most endemic of all countries. These fungi are thermally dimorphic that exhibit two morphotypes, a mold under 28 °C and a yeast in cultures at 35–37 °C, as well as in tissues. Currently, phylogenetic studies divide the cryptic species have been recognized as etiologic agents of this mycosis.1720), and transformed in proceedings in Belize, for History, which left ascribed by Buccaneers. 28), most of which is then published as high-performance and Granular.Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Ergosterol is the main component of the fungal membrane.Its pharmacodynamics has been described with good tolerability, few side effects, and high efficacy against major superficial mycoses [10, 11].DD is directly influenced by a series of factors, such as excessive humidity and skin maceration, which regularly tends to show a change in p H, thereby making it more alkaline.
Sertaconazole is a broad-spectrum third-generation imidazole derivative that is effective and safe for the treatment for superficial mycoses, such as tineas, candidiasis, and pityriasis versicolor.Our goal was to assess the efficacy and safety of sertaconazole cream (2 %) in DDC. There was an average symptom reduction from 7.1 to 3.2 in the middle of treatment and to 1.2 and 0.4 units at the end of treatment and follow-up, respectively.The treatment evaluation at the end of the follow-up period showed a total clinical and mycological cure in 88.8 %, improvement in 3.7 %, and failure in 7.4 %.It should be noted that DD is an inflammatory and irritating acute condition that is not included within mycoses; its association with different yeasts derives from its colonization [6, 7].In general, DD may be treated with desiccants and inert substances.
This mycosis tends to run a chronic progressive course affecting preferentially the lungs and is accompanied by dissemination to mucous membranes, skin, adrenals, and reticuloendothelial system; other localizations include central nervous system (CNS) and bones.